No significance really, as very few coins have clear beading to begin with, plus the bead numbers would vary for each die! Also, double-strike, even by a half a degree would change the orientation of the beads altogether (and numbers, of course)! I guess if you had a couple of extremely well-struck coins from the same die you could certainly utilize the beading in those instances but, on the whole, i don't think you'd convince very many people in the hammered world that your coin was X on account of a point to bead etc., so I'm avoiding that marker altogether...unless there's nothing else left to go on! I keep praying now that all the mint workers were pi**ed on die preparation day, as the misaligned legends are undoubtably the best friend! Ironically, the larger denominations are more difficult, as there are far fewer misalignments and errors, or the cramming in of letters, because they quite literally ran out of space. Also, lest we forget, that blessing of letters encroaching one upon the other! All very interesting if you're a nerd/spotter, I mean collector!